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KMID : 1130620230190040338
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Journal of Clinical Neurology
2023 Volume.19 No. 4 p.338 ~ p.343
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Cerebral Arterial Stiffness as Measured Based on the Pulse Wave Velocity Is Associated With Intracranial Artery Calcification in Patients With Acute Stroke
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Xuelong Li
Heng Du
Jia Li
Xianliang Li
Qingchun Gao
Xiangyan Chen
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Abstract
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Background and Purpose By measuring a newly defined parameter, the carotid?cerebral pulse wave velocity (ccPWV), this study aimed to determine the association of intracranial artery calcification (IAC) with arterial stiffness as reflected by the pulse wave velocity between the carotid and middle cerebral arteries using transcranial Doppler sonography in patients with acute stroke.
Methods We recruited 146 patients with ischemic stroke from our stroke center. Computed tomography of the head was used to assess the presence and severity of IAC. Arterial stiffness was evaluated using ccPWV. Data are presented as quartiles of ccPWV. A multivariable logistic regression model was used to assess the independent relationship between ccPWV and IAC.
Results The IAC prevalence increased with the ccPWV quartile, being 54%, 76%, 83%, and 89% for quartiles 1, 2, 3, and 4, respectively (p<0.001) as did IAC scores, with median [interquartile range] values of 0 [0?2], 3 [2?4], 4 [2?5], and 5 [4?6], respectively (p<0.001). After additionally adjusting for age and hypertension, a significant correlation was only found between quartiles 3 and 4 of ccPWV and IAC scores. The odds ratio (95% confidence interval) for the IAC scores was 1.78 (1.28?2.50) (p=0.001) in quartile 4 of ccPWV and 1.45 (1.07?1.95) (p=0.015) in quartile 3 compared with quartile 1.
Conclusions We found that in patients with acute ischemic stroke, ccPWV was positively related to the degree of IAC. Future longitudinal cohort studies may help to identify the potential role of IAC in the progression of cerebral arterial stiffness.
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KEYWORD
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intracranial arterial calcification, carotid?cerebral pulse wave velocity, computed tomography, arterial stiffness, acute ischemic stroke
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